22-P012 The role of Aminopeptidase O (ApO) in vascular biology and disease

Xenopus model. It provides wild-type, transgenic and mutant frogs to research labs at cost and can now also supply oocytes, embryos and frozen sperm. All of the GA animals are quality controlled to ensure that their offspring have the expected phenotype. In addition to these animal resources EXRC is gathering insitu hybridisation probes, relevant antibodies and expression clones from labs; again these are being quality controlled and then made available to researchers at cost. EXRC also has Xenopus tropicalis fosmid libraries available and full length Xenopus laevis ESTs. In terms of research for the community EXRC has undertaken a large survey of chytrid (Bd) infection of the UK Xenopus colonies and is refining transgenesis techniques. Our main aim in this area currently is to identify transgenic lines that the cell and developmental biology communities require and to produce these at medium throughput.